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基本情況

鄭允文醫(yī)學(xué)博士，特聘教授，博士生導(dǎo)師，研究領(lǐng)域?yàn)楦杉?xì)胞與再生醫(yī)學(xué)，從事中內(nèi)胚層干細(xì)胞和肝膽胰等消化器官體性干細(xì)胞的分離鑒定及細(xì)胞移植治療研發(fā)20余年，致力于前癌干細(xì)胞的發(fā)生機(jī)理研究與靶向藥物開(kāi)發(fā)，近年聚焦胎盤(pán)組織干細(xì)胞、細(xì)胞重編程、干細(xì)胞基因編輯、3D類(lèi)器官再構(gòu)建和移植治療及血液肝臟雙人源化大鼠的研發(fā)工作，并特別傾注于人多能性誘導(dǎo)干細(xì)胞（iPS細(xì)胞）和胚胎干細(xì)胞（ES細(xì)胞）的功能性細(xì)胞分化誘導(dǎo)及其在仿真疾病模擬與創(chuàng)藥研究中的應(yīng)用。

主持和參與日本文部省、日本學(xué)術(shù)振興會(huì)、日本學(xué)術(shù)技術(shù)振興機(jī)構(gòu)、國(guó)家自然科學(xué)基金等研究課題20余項(xiàng)，發(fā)表SCI論文110余篇，在中日美德加新韓7國(guó)獲15項(xiàng)發(fā)明專(zhuān)利授權(quán)，中日美歐新韓澳等國(guó)共申請(qǐng)專(zhuān)利11件次。主導(dǎo)模擬器官自發(fā)形成所需微小環(huán)境研究，在世界上首先利用iPS細(xì)胞誘導(dǎo)并構(gòu)建用于移植治療的肝性類(lèi)器官（Nature 2013），入圍科學(xué)雜志2013年度的“科學(xué)突破”，并遴選為Discovery雜志2013年度科學(xué)進(jìn)展Top5。此外，參與創(chuàng)造性地構(gòu)建了腫瘤類(lèi)器官模型（Nat Cell Biol 2019）并直接主導(dǎo)患者iPS細(xì)胞由來(lái)誘導(dǎo)黑素細(xì)胞移植治療研究（Cell Rep 2019），世界首次構(gòu)建置換率超30%的肝臟人源化大鼠（Adv Sci 2021），利用人類(lèi)iPS細(xì)胞首次實(shí)證衰老致肝細(xì)胞可塑性損害的本質(zhì)為組蛋白低乙?；瑸槔夏耆烁闻K再生能力的改善找到切入點(diǎn)（Hepatology 2022）。還擔(dān)任Elsevier出版社特邀編輯，領(lǐng)銜30余人編撰團(tuán)隊(duì)，總結(jié)了干細(xì)胞與細(xì)胞重編程以及肝腫瘤相關(guān)領(lǐng)域的最新研究成果，編著出版"Stem Cells and Cancer in Hepatology"英文學(xué)術(shù)專(zhuān)著1部。

聯(lián)系方式

529020廣東江門(mén)市東成村22號(hào)五邑大學(xué)藥學(xué)與食品工程學(xué)院

E-mail:[email protected]

教育經(jīng)歷

1986南京大學(xué)，動(dòng)物學(xué)專(zhuān)業(yè)，理學(xué)學(xué)士;

1989南京大學(xué)，細(xì)胞生物學(xué)，理學(xué)碩士;

2003筑波大學(xué)（日本），生理學(xué)專(zhuān)業(yè)，醫(yī)學(xué)博士.

科研經(jīng)歷

1989- 國(guó)家環(huán)境保護(hù)部南京環(huán)科所,助理研究員;

1996- 筑波大學(xué)（日本）醫(yī)學(xué)院臨床醫(yī)學(xué)系,助理研究員;

2003- 日本學(xué)術(shù)振興會(huì),博士后；橫濱市立大學(xué)（日本）醫(yī)學(xué)部臟器再生醫(yī)學(xué)系,特別研究員,干細(xì)胞與再生醫(yī)學(xué);

2005- 橫濱市立大學(xué)（日本）醫(yī)學(xué)部臟器再生醫(yī)學(xué)系，助理教授,干細(xì)胞與再生醫(yī)學(xué);

2015- 筑波大學(xué)（日本）醫(yī)學(xué)醫(yī)療系，副教授/PI研究員,干細(xì)胞與再生醫(yī)學(xué)；

橫濱市立大學(xué)（日本）醫(yī)學(xué)研究科臟器再生醫(yī)學(xué)系, 客座副教授;

2022-東京大學(xué)（日本）醫(yī)科學(xué)研究所，干細(xì)胞治療研究中心再生醫(yī)學(xué)方向項(xiàng)目研究員；

東京理科大學(xué)（日本）藥學(xué)部，生命創(chuàng)藥科學(xué)科分子醫(yī)科學(xué)方向客座教授;

2023-五邑大學(xué)生物科技與大健康學(xué)院，廣東省醫(yī)學(xué)大動(dòng)物模型重點(diǎn)實(shí)驗(yàn)室，特聘教授，博士生導(dǎo)師.

榮譽(yù)獎(jiǎng)項(xiàng)與學(xué)術(shù)活動(dòng)

江蘇省高層次創(chuàng)新創(chuàng)業(yè)人才，江蘇特聘醫(yī)學(xué)專(zhuān)家;

日本學(xué)術(shù)振興會(huì)特別研究員/博士后（Postdoctoral Fellowship of JSPS）;

日本臟器保存生物醫(yī)學(xué)會(huì)評(píng)議員/理事（Japan Society for Organ Preservation and Biology）;

日本醫(yī)生物學(xué)研究會(huì)召集人（Japan Liver Biology Study Group）;

日本再生醫(yī)療學(xué)會(huì)會(huì)員（Japanese Society for Regenerative Medicine）;

日本癌學(xué)會(huì)會(huì)員(Japanese Cancer Association);

日本肝細(xì)胞研究會(huì)會(huì)員(Japanese Society for Hepatocellular Research);

國(guó)際干細(xì)胞研究學(xué)會(huì)會(huì)員(International Society for Stem Cell Research);

學(xué)術(shù)雜志編委：PLoS One, World Journal of Stem Cells, Cells;

學(xué)術(shù)雜志特邀編委: Stem Cells International, JOVE.

主要研究方向

1. 1. 多能性干細(xì)胞的分化誘導(dǎo)與組織再構(gòu)建及疾病模型；

2. 2. 多能性干細(xì)胞由來(lái)肝類(lèi)器官與人源化大鼠及創(chuàng)新藥物研發(fā)；

3. 3. 組織干細(xì)胞與成瘤機(jī)理及細(xì)胞移植治療模型；

4. 4. 肝再生與血液互作；

5. 5. 日夜節(jié)律與神經(jīng)內(nèi)分泌及代謝調(diào)控.

近五年主要研究課題

1. 1. 國(guó)家自然科學(xué)基金面上項(xiàng)目 基于hiPSC來(lái)源肝類(lèi)器官與血液微環(huán)境互作模型的NASH動(dòng)態(tài)模擬與藥物篩選 2023.01-2026.12 核心參與;

2. 2. 日本東京大學(xué)醫(yī)科學(xué)研究所國(guó)際合作項(xiàng)目 iPSC由來(lái)肝性類(lèi)器官的肝臟人源化大鼠的創(chuàng)出2022.04-2025.03 主持;

3. 3. 國(guó)家自然科學(xué)基金面上項(xiàng)目 患者iPSC來(lái)源肝組織構(gòu)成細(xì)胞的高效誘導(dǎo)擴(kuò)增及其功能性肝臟類(lèi)器官的構(gòu)建與移植評(píng)估 2021.01-2024.12 主持;

4. 4. 日本學(xué)術(shù)振興會(huì)基盤(pán)研究B 體性干細(xì)胞用于治療肝硬化肝衰竭的新型再生醫(yī)療核心技術(shù)的研究開(kāi)發(fā)2018.04-2022.03 主持;

5. 5. 國(guó)家自然科學(xué)基金面上項(xiàng)目 肝臟類(lèi)器官的自律性形成和具有人源化免疫系統(tǒng)的人肝嵌合大鼠的構(gòu)建 2018.01-2021.12 主持;

6. 6. 日本學(xué)術(shù)振興會(huì)萌芽研究 具有人源化肝臟和免疫系統(tǒng)的肝病模型的構(gòu)建 2016.04-2019.03 主持.

近五年主要論著（*第一作者，#通訊作者）

1. 1. Tan C, Ding M, Zheng YW^#. The Values and Perspectives of Organoids in the Field of Metabolic Syndrome. Int J Mol Sci 2023, 24, 8125.

2. 2. Liu LP^#, Li MH, Zheng YW^#. Hair Follicles as a Critical Model for Monitoring the Circadian Clock. Int J Mol Sci. 2023;24(3):2407.

3. 3. Nie YZ, Zheng YW#, Taniguchi H#. Improving the repopulation capacity of elderly human hepatocytes by decoding aging-associated hepatocyte plasticity. Hepatology. 2022;76(4):1030-45.

4. 4. Chen YY, Liu LP, Zhou H, Zheng YW^#, Li YM^#. Recognition of Melanocytes in Immuno-Neuroendocrinology and Circadian Rhythms: Beyond the Conventional Melanin Synthesis. Cells. 2022;11(13):2082.

5. 5. Zhang YX, Chen SL, Li YM#, Zheng YW^#. Limitations and challenges of direct cell reprogramming in vitro and in vivo. Histol Histopathol. 2022;18458.

6. 6. Liu LP*, Zheng DX*, Xu ZF, Zhou HC, Wang YC, Zhou H, Ge JY, Sako D, Li M, Akimoto K, Li YM^#, and Zheng YW^#. Transcriptomic and Functional Evidence Show Similarities between Human Amniotic Epithelial Stem Cells and Keratinocytes, Cells (Basel) 2021; 11(1):70.

7. 7. Zhang L*, Ge JY*, Zheng YW*,^#, Sun Z, Wang C, Peng Z, Wu B, Fang M, Furuya K, Ma X, Shao Y, Ohkohchi N, Oda T, Fan J, Pan G, Li D^#, Hui L^#. Survival-Assured Liver Injury Pre-Conditioning (SALIC) enables robust expansion of human hepatocytes in Fah^-/-Rag2^-/-IL2rg^-/- rats. Adv Sci (Weinh) 2021; 8(19): e2101188.

8. 8. Furuya K*, Zheng YW*,#, Ge JY, Zhang L, Furuta T, Liang C, Abe H, Yagi H, Hamada H, Isoda H, Hui L, Ohkohchi N, Oda T. The evidence of a macrophage barrier in the xenotransplantation of human hematopoietic stem cells to severely immunodeficient rats. Xenotransplantation 2021; 28(4): e12702.

9. 9. Zhou H*, Wang Y*, Liu LP^#, Li YM^#, Zheng YW^#, Gene Editing in Pluripotent Stem Cells and Their Derived Organoids, Stem Cells Int 2021; 2021:8130828.

10. 10. Wang Y, Cao D, Chen SL, Li YM, Zheng YW^#, Ohkohchi N. Current trends in three-dimensional visualization and real-time navigation as well as robot-assisted technologies in hepatobiliary surgery. World J Gastrointest Surg 2021;13(9):904-22.

11. 11. Cao D*, Ge JY*, Wang Y, Oda T, Zheng YW^#. Hepatitis B virus infection modeling using multi-cellular organoids derived from human induced pluripotent stem cells. World J Gastroenterol 2021;27(29):4784-801.

12. 12. Xu MX*, Liu LP*, Li YM^#, Zheng YW^#. The Opportunities and Challenges regarding Induced Platelets from Human Pluripotent Stem Cells. Stem Cells Int 2021;2021:5588165.

13. 13. Ge JY*, Zheng YW*,^#, Tsuchida T, Furuya K, Isoda H, Taniguchi H^#, Ohkohchi N and Oda T. Hepatic stellate cells contribute to liver regeneration through galectins in hepatic stem cell niche. Stem Cell Res Ther. 2020; 11: 425.

14. 14. Fang M*, Liu LP*, Zhou H, Li YM^#, Zheng YW^#. Practical choice for robust and efficient differentiation of human pluripotent stem cells. World J Stem Cells 2020;12(8):752-60.

15. 15. Guo NN, Liu LP, Zheng YW^#, Li YM^#. Inducing human induced pluripotent stem cell differentiation through embryoid bodies: A practical and stable approach. World J Stem Cells 2020. 12(1): 25-34.

16. 16. Sun L, Wang Y, Cen J, Ma X, Cui L, Qiu Z, Zhang Z, Li H, Yang RZ, Wang C, Chen X, Wang L, Ye Y, Zhang H, Pan G, Kang JS, Ji Y, Zheng YW^#, Zheng S^#, and Hui L^#. Modeling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes. Nat Cell Biol 2019.21(8):1015-26.

17. 17. Furuya K, Zheng YW^#, Sako D, Iwasaki K, Zheng DX, Ge JY, Liu LP, Furuta T, Akimoto K, Yagi H, Hamada H, Isoda H, Oda T and Ohkohchi N. Enhanced hepatic differentiation in the subpopulation of human amniotic stem cells under 3D multicellular microenvironment. World J Stem Cells 2019. 11(9):705-21.

18. 18. Guo NN, Liu LP, Zhang YX, Cai YT; Guo Y, Zheng YW^#, Li YM^#. Early prediction of the differentiation potential during the formation of human iPSC-derived embryoid bodies. Biochem Biophys Res Commun 2019. 516(3):673-79.

19. 19. Liu LP, Li YM^#, Guo NN, Li S, Ma XL, Zhang YX, Gao YM, Huang JL, Zheng DX, Wang LY, Xu H, Hui L^#, Zheng YW^#. Therapeutic potential of patient iPSC-derived iMelanocytes in autologous transplantation. Cell Rep 2019. 27(2):455-66.e5.

20. 20. Ge JY, Zheng YW^#, Liu LP, Isoda H and Oda T. Impelling force and current challenges by chemicals in somatic cell reprograming and expansion beyond hepatocytes. World J Stem Cells 2019. 11(9):650-65.

21. 21. Liu LP, Zheng YW^#. Predicting differentiation potentials of human pluripotent stem cells: Possibilities and challenges. World J Stem Cells 2019.11(7): 375-82. (Editorial).

22. 22. Nie YZ*, Zheng YW*,#, Miyakawa K, Murata S, Zhang RR, Sekine K, Ueno Y, Takebe T, Wakita T, Ryo A, Taniguchi H^#. Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells. EBioMedicine 2018; 35:114-23 (Cover image).

23. 23. Zhang RR*, Zheng YW*,^#, Li B, Nie YZ, Ueno Y, Tsuchida T, Taniguchi H^#. Hepatic stem cells with self-renewal and liver repopulation potential are harbored in CDCP1-positive subpopulations of human fetal liver cells. Stem Cell Res Ther 2018. 9(1):29.

24. 24. Nie YZ*, Zheng YW*,^#, Ogawa M, Miyagi E, Taniguchi H^#. Human liver organoids generated with single donor-derived multiple cells rescue mice from acute liver failure. Stem Cell Res Ther 2018. 9(1):5.

25. 25. Liu LP, Li YM, Guo NN, Wang LY, Isoda H, Ohkohchi N, Taniguchi H and Zheng YW^#. Generation of liver organoids and their potential applications. In Stem Cells and Cancer in Hepatology: From Essentials to Application (edited by Zheng YW). ELSEVIER, 2018, pp115-44. ISBN 9780128123010.